Troublesome Psychotic Astronaut?

No problem!:

... the astronaut's crewmates should bind his wrists and ankles with duct tape, tie him down with a bungee cord and inject him with tranquilizers if necessary.

"Talk with the patient while you are restraining him," the instructions say. "Explain what you are doing, and that you are using a restraint to ensure that he is safe."

The instructions do not spell out what happens after that. ... The crew members might have to rely in large part on brute strength to subdue an out-of-control astronaut, since there are no weapons on the space station or the shuttle. A gun would be out of the question; a bullet could pierce a spaceship and could kill everyone.

... Space station medical kits contain tranquilizers and anti-depression, anti-anxiety and anti-psychotic medications. ... The checklist says say astronauts who crack up can be restrained and then offered oral Haldol, an anti-psychotic drug used to treat agitation and mania, and Valium.

... During missions in 1985 and 1995, shuttle commanders put padlocks on the spaceships' hatches as a precaution since they didn't know the scientists aboard very well. Some crew members, called payload specialists, are picked to fly for specific scientific or commercial tasks and do not train as extensively with the other astronauts.

But still no ideas about how to deal with a troublesome psychotic onboard computer system. Bring out the duct tape and you're likely to get "I wouldn't do that if I were you, Dave!"