Getting Optimistic About Cancer

A cure?

“We believe we will offer in a year’s time a complete cure for cancer,” said Dan Aridor, chairman of the board of Accelerated Evolution Biotechnologies Ltd. (AEBi), a company founded in 2000 in the ITEK incubator in the Kiryat Weizmann Science Park in Ness Ziona, Israel, just north of the Weizmann Institute of Science in Rehovot, Israel. A development-stage biopharmaceutical company engaged in discovery and development of therapeutic peptides, AEBi developed the SoAP platform, a combinatorial biology screening platform technology, which provides functional leads—agonist, antagonist, inhibitor, etc.—to very difficult targets.

...Morad said most anti-cancer drugs attack a specific target on or in the cancer cell. “Inhibiting the target usually affects a physiological pathway that promotes cancer. Mutations in the targets – or downstream in their physiological pathways – could make the targets not relevant to the cancer nature of the cell, and hence the drug attacking it is rendered ineffective,” he told The Jerusalem Post.

“In contrast, MuTaTo is using a combination of several cancer-targeting peptides for each cancer cell at the same time, combined with a strong peptide toxin that would kill cancer cells specifically,” Morad said. “By using at least three targeting peptides on the same structure with a strong toxin, we made sure that the treatment will not be affected by mutations; cancer cells can mutate in such a way that targeted receptors are dropped by the cancer.”

“The probability of having multiple mutations that would modify all targeted receptors simultaneously decreases dramatically with the number of targets used,” Morad continued. “Instead of attacking receptors one at a time, we attack receptors three at a time – not even cancer can mutate three receptors at the same time.”

Bob Odenkirk's Ode To Winter

Cold....

Winter in Chicago can just be a mean, mean honesty. Cruel, low-down—a brittle, impossible wall of metaphysical truth encircling you and pounding away. And at night it’s worse, if you’ve got to take the garbage out, or head home from your crap job at midnight (I wasn’t always in show biz) or after breaking up with someone and riding your bike to your lonely apartment at 2 a.m. over 15 inches of craggy, frozen snow that crunches with that dry, chalk-on-chalkboard squerk that makes your spine shake its fists at your brain

Mostly Just Watched Dancehall Tonight

Feeling under the weather, so mostly just watched Dancehall tonight. Some nice tunes, though!

Remarkable Warmth in California

A necessary complement to the bitter cold affecting the Great Lakes area is the remarkable warmth in California. I’ve got the back door open so the house can air out. Leaf buds that usually wait a week are making an appearance now.

A Good Word For Meteorologists

Very accurate!:

Meteorologists have never gotten a shiny magazine cover or a brooding Aaron Sorkin film, and the weather-research hub of Norman, Oklahoma, is rarely mentioned in the same breath as Palo Alto. But over the past few decades, scientists have gotten significantly—even staggeringly—better at predicting the weather.

How much better? “A modern five-day forecast is as accurate as a one-day forecast was in 1980,” says a new paper, published last week in the journal Science. “Useful forecasts now reach nine to 10 days into the future.”

The paper is a birthday present from meteorology to itself: The American Meteorological Society turns 100 this year. But it also acts as a good report card on how far weather prediction has come.

“Modern 72-hour predictions of hurricane tracks are more accurate than 24-hour forecasts were 40 years ago,” the authors write. The federal government now predicts storm surge, stream level, and the likelihood of drought. It has also gotten better at talking about its forecasts: As I wrote in 2017, the National Weather Service has dropped professional jargon in favor of clear, direct, and everyday language.

Surprised This Wasn't Albuquerque

Confusion:

The incident occurred in November when officers from the 12th precinct in Detroit went undercover with the purpose of pretending to be drug dealers so they could arrest buyers. Two buyers went to the house where the pretend drug dealing police officers were but they were actually police going undercover to arrest people selling drugs. They were from the 11th district of Detroit police. They began to search the place when they arrived and they were wearing body cams that captured the whole incident of the officers fighting and punching each other.

Pour

Fanboys (2008)

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Last updated: March 15, 2020.

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Comedy/drama. Young men make a pilgrimage road trip to Skywalker Ranch in an attempt to get a screening of the new Star Wars movie for their terminally ill friend. Starring am Huntington,, Jay Baruchel, Kristen Bell, Seth Rogan, Thom Bishops, and Charlie B. Brown. Filmed around Albuquerque and Las Vegas.




Notes on Individual Scenes
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Pop 'N Taco - NE corner of Edith and Central Ave. NE.

Hole in the Wall Comics - Comic Warehouse, 9617 Menaul Blvd. NE.

Hole in the Wall Comics - Comic Warehouse, 9617 Menaul Blvd. NE (February 2020).

Crazy Heart (2009)

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Last updated: May 30, 2019.

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https://www.imdb.com/title/tt1263670/locations
http://www.city-data.com/forum/santa-fe/884637-sf-locations-movie-crazy-heart.html


Jeff Bridges stars as a has-been country musician seeking redemption and a comeback. Also stars Maggie Gyllenhaal, Robert Duvall, and Colin Farrell. Filming locations: Albuquerque BioPark Aquarium, Albuquerque Convention Center, Albuquerque First Plaza Galeria, Espanola, Galisteo, Old St. Vincent Hospital (Santa Fe), Santa Fe, Santa Fe Opera.



Notes on Individual Scenes
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Landscapes - Northern NM

San Ildefono

Bowling Alley - SE quadrant of the intersection of Mountain View St. and N. Riverside Drive in Española.

Starlite Lounge

Liquor Store

Santa Fe Bar - Evangelo's Cocktail Lounge, 200 W. San Francisco Street, Santa Fe, NM.

Motel in Santa Fe

Santa Fe Opera, lower esplanade

Maybe rest of Santa Fe Opera too.

Sandia Amphitheater in Albuquerque? - unverified

Room 4, 10764..... - unverified.

Currently the Isleta Amphitheater, formerly The Pavilion, 5601 University Blvd. SE.

The Pavilion.

Paul's Monterey Inn, formerly at 1000 Juan Tabo Blvd. NE.

[UPDATE: February, 2015: Sad news that Paul's Monterey Inn will close after 40 years in business. This article from January, 2014 identifies tax issues as a major burden. And once again, time is quickly erasing the Albuquerque's movie heritage.]

Where Maggie meets Bad? - La Villa de Thunderbird Inn, 1821 Cerrillos Rd., Santa Fe, NM? - Unverified.

Hospital - St. Vincent's Regional Medical Center, 405 St. Michael's Drive, Santa Fe, NM? - Unverified.
Old St. Vincent Hospital - 228 E. Palace Avenue, Santa Fe, New Mexico, USA - Unverified.

Various fields and scenic views

Santa Fe house

Houston cityscape

Houston house

Fishing

ABQ BioPark Aquarium Shark Tank, 2601 Central Ave. NW, Albuquerque, NM.

Albuquerque First Plaza Galleria, 20 First Plaza Ctr NW, Albuquerque, NM

La Esquina Restaurante, 40 First Plaza Ctr NW # 60, Albuquerque, NM 87102

AA Meeting

Have The Annual Cold

Yuck!

After the Fall (2014)

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Last Updated March 2, 2020

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AKA: Things People Do. Crime drama starring Wes Bentley, Vinessa Shaw, Haley Bennett, Jason Isaacs and Audrey Walters. Filming locations: Albuquerque, Los Lunas, and Rio Rancho.



Notes on Individual Scenes
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Junkyard - Possibly Five J's Auto Parts.

An amusing Muscle Man poses at the lobby door of Five J's, 5404 Broadway Blvd SE.

Ruined house

Playground Equipment

Family Home with swimming pool - 6816 Augusta Hills Dr. NE, Rio Rancho, NM

There is a reference to the Radisson Water Park: Wyndham Albuquerque Hotel & Conference Center, 2500 Carlisle Blvd NE.

Street scene - Boulder Rd. NE, Rio Rancho (35.343162°, -106.612157°)

Fancy House - Unresolved

Forlorn parking lot was located in the Jubilee real estate development near Highway 6 west of Los Lunas (34.816705°, -106.793899°). The parking lot has since been replaced by houses, and no longer exists.

Holiday Bowl - 7515 Lomas Blvd. NE.

Dog scavenges from garbage can.

Highway 6 west of Los Lunas (34.820248°, -106.788511°).

Second St. SW near Railyards.

Railyards.

Railyards.

Railyards.

Railyards.

Eastbound on Lomas Blvd. at San Mateo (Taco Bell, Ace Hardware)

Forlorn parking lot again.

Diner

Cash Place

Convenience Store - Probably Y-Mart, Coal and Graceland SE.

A former Circle-K convenience store at "The Y", where Lead and Coal Avenues meet.

Gas Station/Pawn Shop - Bernalillo Motors & Towing LLC, 2720 Coors Blvd SW, Albuquerque.

Car Wash

Forlorn Tree

View of Sandia Crest, and city as seen from the Crest.

Invaded House - Sales Center - Unresolved, but probably in Jubilee area of Los Lunas.

Playground Unresolved.

After the Fall - Tijeras Arroyo

New apartment building - possibly Radisson?

Gas station

School

Railroad underpass on Central Ave.

Jubilee Rd. turnoff on Highway 6 west of Los Lunas.

Long shot of the Big-I, Intersection of I-40 & I-25.

Broadway at Central Ave.

Hi-Lo Market, 2513 4th Street NW.

Very quick view of Loyola's Restaurant on Central Ave.

Police Dept., 400 Roma Ave. NW, as seen from Marquette Avenue.

Police Dept.

Savings and Loan - Unresolved

Downtown office

New York Ave. and Central Ave. NW

Desert Sands Motel, Albuquerque, 5000 Central Avenue SE (now, sadly, gone...).

Desert Sands Motel, Albuquerque, 5000 Central Avenue SE.

Something spooky there.

Father's home

Green Motel Sign

Alameda Bridge over the Rio Grande River.

Foreclosed house

House in valley

Police stop.

Street scene near Family Home



Locations in deleted scenes: under the Coal Ave. Overpass over the railroad, and in Tijeras Arroyo.

Swing Vote (2008)

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Last updated March 12, 2020

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Comedy / Drama. The outcome of a presidential election hangs a New Mexico man's vote. Starring Kevin Costner, Kelsey Grammer, Stanley Tucci, Dennis Hopper, Paula Patton, George Lopez, Nathan Lane, Mare Winningham, Judge Reinhold, Madeline Carroll, Willie Nelson, Richard Petty, Arianna Huffington. Filming locations: Albuquerque, Belen, Corrales, Los Ranchos de Albuquerque, Santa Fe.



Notes on Individual Scenes
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Belen's Becker Avenue & 2nd St. is a primary movie location.

E. Garcia Grocery & Meat Market - Eva's Chile.

Possible playground scene location.

Gilmore Eggs. Located at Cal-Maine Foods, 9615 Broadway Blvd. SE, near Broadway Blvd. SE & I-25.

Texico Sign (Unknown)

Gas Station

Posse Bingo Hall and Dance Palace - voting location. Sheriff's Posse Hall, Valencia Fair, 10 I-25 Bypass, Belen.

Posse Bingo Hall and Dance Palace - voting location. Sheriff's Posse Hall, Valencia Fair, 10 I-25 Bypass, Belen.

Vicinity of La Bajada Hill on Highway 16 - (35.528598°, -106.238987°)

Drive - Unknown

Playground and School - Unknown

White House, Washington D.C.

Campaign Site - Woodsy Area - Unknown

Office - Unknown

School – Harwood Art Center, 1114 7th St NW, Albuquerque, NM

Foosball in Bar - Becker St. Pub, 208 Becker Ave.

Trophy shop.

House - Unknown

Various Sites

Reinken Avenue at 3rd St., including overpass.

Looking towards overpass on Reinken Avenue over railroad.

Café 66, 9200 Central Avenue SW.

Campaign HQ - Unknown

Rio Grande River - Corrales - pictures from New Year's Day, 2006 (35.199366°, -106.642605°)

Mobile Home Park - External View - 601 Camino del Llano (34.654621°, -106.775401°)

View across irrigation ditch.

TV Station - KNME TV, Albuquerque?

School yard

Sunport/KAFB

Shopping Center - Del Rio Plaza, 106 Caldwell Avenue, at Reinken Avenue (34.658921°, -106.759623°).

Beall's Shopping Plaza.

Former location of Greenleaf for President campaign headquarters.

Swing Vote - flipped image - Richard Petty - (35.499728°, -106.232735°)

Bobby Foster Road?

Line of undocumented actors

Shooting range - west of Belen - exact location unknown

Bowling alley - Becker Ave., Belen?

Playground?

School - Downtown ABQ?

Outside Air Force 1 - Sunport and near intersection of Highway 16 and Tetilla Peak Rd.

Kate Madison's House - Unknown

Playground? - (34.654249°, -106.757841°) - Associated with Rio Grande Elementary School

Albuquerque apartments?

Rodeo De Santa Fe - Rodeo - 3237 Rodeo Rd, Santa Fe, NM 87502